氮硫杂环化合物在化学、药学、生物学和材料科学等领域具有广阔的应用前景，

Nitrogen-sulfur heterocyclic compounds have broad application prospects in the fields of chemistry, pharmacy, biology, and materials science. Chemists have <br>developed various methods to construct nitrogen-sulfur heterocyclic compound skeletons, in which transition metals are used to catalyze CH functionalization/ringing. It is a very effective method to construct nitrogen- <br>sulfur heterocyclic compounds by involving inorganic sulfur sources in CH functionalization/cyclization to construct nitrogen-sulfur heterocyclic compounds. <br>Page 3 of 20 . <br>Currently, chemists have developed a variety of effective methods to construct <br>common benzothiazole and other five-membered nitrogen-sulfur heterocyclic compounds. However, for six-membered nitrogen-sulfur heterocyclic compounds and five-membered heterocyclic benzisothiazoles <br>, especially benzo[c ] isothiazoles, there is still a lack of effective synthesis methods. This project plans to use the easily available and stable N-(1- <br>phenylethyl)aniline compounds and o-alkynyl arylamines as substrates to undergo a series cyclization reaction with an inorganic sulfur source to construct thiazide <br>compounds and benzo[ c] Isothi (selenium) azoles. Through substrate design and condition optimization, develop an efficient, highly selective <br>, and mild transition metal-catalyzed tandem cyclization method to synthesize nitrogen and sulfur cyclic compounds; at the same time, <br>explore the reaction mechanism through modern analysis and testing methods; and use this method And technology is applied to the synthesis of some natural products and drug molecules and frameworks <br>. Provide theoretical and experimental basis for the synthesis and application research of nitrogen-sulfur heterocyclic compounds.

Nitrogen sulfur heterocyclic compounds have broad application prospects in fields such as chemistry, pharmacy, biology, and materials science. Chemists<br>Various methods have been developed to construct frameworks for nitrogen sulfur heterocyclic compounds, among which transition metals are used to catalyze C-H functionalization/cyclization reactions<br>Study on the involvement of inorganic sulfur sources in C-H functionalization/cyclization to construct nitrogen sulfur heterocyclic compounds<br>Page 3 of 20<br>Constructing nitrogen sulfur heterocyclic compounds is a very effective method. Currently, chemists have developed various effective methods to construct<br>Common five membered nitrogen sulfur heterocyclic compounds such as benzothiazole, but for six membered nitrogen sulfur heterocyclic and five membered heterocyclic benzoisothiazole<br>Especially for benzo [c] isothiazole, there is still a lack of effective synthesis methods. This project aims to utilize N - (1), which is easy to obtain and stable-<br>Phenylethyl) aniline compounds and o-acetylarylamine as substrates undergo series cyclization reaction with inorganic sulfur sources to construct thiazides<br>Compounds and benzo [c] isothiazole (selenium) compounds. Developing efficient and highly selective substrates through substrate design and condition optimization<br>Method for synthesizing nitrogen sulfur cyclic compounds through mild transition metal catalyzed series cyclization reaction; Simultaneously, through modern analysis<br>And testing methods to explore the reaction mechanism; And apply this method and technology to some natural products, drug molecules, and frameworks<br>Synthesis. Provide theoretical and experimental basis for the synthesis and application research of nitrogen sulfur heterocyclic compounds.

Nitrogen-sulfur heterocyclic compounds have broad application prospects in the fields of chemistry, pharmacy, biology and material science, and chemists<br> Various methods have been developed to construct the skeleton of nitrogen-sulfur heterocyclic compounds, in which transition metals are used to catalyze C-H functionalization/cyclization.<br> Study on inorganic sulfur source participating in C-H functionalization/cyclization to construct nitrogen-sulfur heterocyclic compounds<br> Page 3, 20 pages in total<br> It is a very effective method to construct nitrogen-sulfur heterocyclic compounds. At present, chemists have developed a variety of effective methods to construct<br> Common five-membered nitrogen-sulfur heterocyclic compounds such as benzothiazole, but for six-membered nitrogen-sulfur heterocyclic compounds and five-membered heterocyclic benzisothiazole,<br> Especially benzo [c] isothiazole, there is still a lack of effective synthetic methods. This project intends to use the simple, easy-to-obtain and stable N-(1-<br> Phenylethyl) aniline compounds and o-alkynyl aromatic amines are used as substrates, which undergo a series cyclization reaction with inorganic sulfur sources to construct thiazides.<br> Compounds and benzo [c] isothiazoles. Develop high efficiency and high selectivity through substrate design and condition optimization.<br> A method for synthesizing nitrogen-sulfur cyclic compounds by series cyclization catalyzed by transition metals with mild conditions; At the same time, through modern analysis<br> And testing means to explore the reaction mechanism; The method and technology are applied to some natural products and drug molecules and skeletons.<br> Synthesis. It provides theoretical and experimental basis for the synthesis and application of nitrogen-sulfur heterocyclic compounds.