Nitrogen-sulfur heterocyclic compounds have broad application prospects in the fields of chemistry, pharmacy, biology and material science, and chemists<br> Various methods have been developed to construct the skeleton of nitrogen-sulfur heterocyclic compounds, in which transition metals are used to catalyze C-H functionalization/cyclization.<br> Study on inorganic sulfur source participating in C-H functionalization/cyclization to construct nitrogen-sulfur heterocyclic compounds<br> Page 3, 20 pages in total<br> It is a very effective method to construct nitrogen-sulfur heterocyclic compounds. At present, chemists have developed a variety of effective methods to construct<br> Common five-membered nitrogen-sulfur heterocyclic compounds such as benzothiazole, but for six-membered nitrogen-sulfur heterocyclic compounds and five-membered heterocyclic benzisothiazole,<br> Especially benzo [c] isothiazole, there is still a lack of effective synthetic methods. This project intends to use the simple, easy-to-obtain and stable N-(1-<br> Phenylethyl) aniline compounds and o-alkynyl aromatic amines are used as substrates, which undergo a series cyclization reaction with inorganic sulfur sources to construct thiazides.<br> Compounds and benzo [c] isothiazoles. Develop high efficiency and high selectivity through substrate design and condition optimization.<br> A method for synthesizing nitrogen-sulfur cyclic compounds by series cyclization catalyzed by transition metals with mild conditions; At the same time, through modern analysis<br> And testing means to explore the reaction mechanism; The method and technology are applied to some natural products and drug molecules and skeletons.<br> Synthesis. It provides theoretical and experimental basis for the synthesis and application of nitrogen-sulfur heterocyclic compounds.
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