T淋巴细胞亚群及IL-6、PCT在脓毒血症患者病情严重程度的相关性研究

Correlation study and clinical significance of T lymphocyte subsets and IL-6 and PCT in patients with sepsis. <br><br>Abstract: Objective: To <br><br>evaluate T lymphocyte subsets and IL-6 and PCT in patients with sepsis. Relevance and clinical significance of severity. <br><br>Methods: <br>120 patients with sepsis admitted to our hospital were selected and divided into three groups according to the severity of the disease: sepsis group, severe sepsis group, and septic shock group, each with 40 cases. <br><br>After admission, all patients used sterile vacuum blood collection tubes to draw venous blood to detect T lymphocyte subsets CD3+, CD4+, CD8+, CD4+/CD8+ levels. At the same time, venous blood was collected to detect interleukin 6 (IL-6). Procalcin (PCT) level. <br><br>Compare and analyze whether there are differences between the three groups of patients, and analyze whether there is any correlation between the level of each index and the patient's recovery after treatment. <br><br>Results: <br><br>The CD3+, CD4+, CD4+/CD8+ levels of the three groups of patients decreased with the aggravation of the disease, with a significant difference (p=0.00). <br><br>The levels of IL-6 and PCT among the three groups increased with the worsening of the disease, and the difference was statistically significant (IL-6, p=0.00; PCT, p=0.01); the better the patients, CD4+, CD4+/CD8+ The higher the levels of the two indicators, the positive correlation between the two; the lower the levels of IL-6 and PCT, the negative correlation between the two. <br><br>Conclusion: <br><br>Peripheral blood T lymphocyte subsets and serum IL-6 and PCT are abnormally expressed in patients with sepsis, and are closely related to the severity of the disease, which can have a certain predictive value for patients after recovery. Therefore, the above indicators have high clinical significance. <br><br>Keywords: T lymphocyte subsets, IL-6, PCT, sepsis, diagnosis

The correlation between T lymphocyte subposes and IL-6 and PCT in the severity of sepsis patients was studied and clinically significant<br><br>Summary: Purpose:<br><br>The correlation and clinical significance of T lymphocyte substation and IL-6 and PCT in sepsis patients were evaluated.<br><br>Method:<br>The 120 cases of sepsis treated in our hospital were selected and divided into three groups according to the severity of the disease: sepsis group, severe sepsis group, sepsis shock group, each group of 40 cases.<br><br>All patients were admitted to the hospital using sterile vacuum blood vessels to extract venous blood, detection of T lymphocyte sub-group CD3, CD4 plus, CD8 plus, CD4 plus / CD8 plus levels, while retaining intravenous blood to detect leukocyte interleukin 6 (IL-6), calcitoninogen (PCT) level.<br><br>The differences between the three groups of patients were compared, and the correlation between the level of each indicator and the condition of patients after treatment was analyzed.<br><br>Results:<br><br>The levels of CD3, CD4, CD4, /CD8, decreased with the aggravation of the disease in three groups of patients, with significant differences (p-0.00).<br><br>The level of IL-6 and PCT increased with the aggravation of the disease between the three groups, and the difference was statistically significant (IL-6, p-0.00; PCT, p-0.01);<br><br>Conclusion:<br><br>The abnormal expression of the abnormal expression in the sub-group and serum IL-6 and PCT of the outer blood T lymphocytes in patients with sepsis is closely related to the severity of the disease, which can have certain predictive value to the patient after healing, so the above indicators have high clinical significance.<br><br>Keywords: T lymphocyte sub-group, IL-6, PCT, sepsis, diagnosis

Correlation of T lymphocyte subsets, IL-6 and PCT in sepsis patients and its clinical significance<br>Abstract: Objective: To investigate the clinical application of this method<br>Objective to evaluate the correlation and clinical significance of T lymphocyte subsets, IL-6 and PCT in sepsis patients.<br>method:<br>120 patients with sepsis in our hospital were selected and divided into three groups according to the severity of the disease: sepsis group, severe sepsis group, sepsis shock group, 40 cases in each group.<br>After admission, venous blood was collected from all patients by aseptic vacuum vessel to detect the levels of T lymphocyte subsets CD3 +, CD4 +, CD8 +, CD4 + / CD8 +, and the levels of interleukin-6 (IL-6) and procalcitonin (PCT).<br>Compare and analyze whether there are differences among the three groups of patients, and analyze whether there is correlation between the level of each index and the prognosis of patients after treatment.<br>result:<br>The levels of CD3 +, CD4 +, CD4 + / CD8 + in the three groups decreased with the aggravation of the disease, with significant difference (P = 0.00).<br>The levels of IL-6 and PCT increased with the aggravation of the disease among the three groups, and the difference was statistically significant (IL-6, P = 0.00; PCT, P = 0.01); the better the patients were, the higher the levels of CD4 +, CD4 + / CD8 + were, the positive correlation between them; while the lower the levels of IL-6 and PCT, the negative correlation between them.<br>Conclusion<br>Peripheral blood T lymphocyte subsets and serum IL-6, PCT showed abnormal expression in patients with sepsis, and has a close relationship with the severity of the disease, can have a certain predictive value for patients after recovery, so the above indicators have high clinical significance.<br>Key words: T lymphocyte subsets, IL-6, PCT, sepsis, diagnosis<br>