原料药被适量称取并置于棕色样品瓶中，具有按表3.2.P.2.1-1不同

The drug substance is weighed appropriately and placed in a brown sample bottle, with different solvents added according to Table 3.2.P.2.1-1 to configure to the corresponding target concentration, ultrasonically dispersed for 20 seconds to make it uniform, and then placed at 200 rpm After shaking overnight at 25 ° C, it was taken out, centrifuged at 10,000 rpm for 10 min, the supernatant was sucked and diluted with a corresponding multiple of the corresponding solvent, and the concentration was measured by HPLC. The results are shown in Table 3.2.P.2.1-1.

The API is weighed in and placed in a brown sample bottle, with a different solvent added according to Table 3.2.P.2.1-1 to be configured to the corresponding target concentration, ultrasonic 20 seconds to disperse it evenly, and then placed at 200 rpm, 25 degrees C Shake overnight, then remove, at 10000 rpm centrifugation 10 min, absorb the liquid and use the corresponding solvent diluted by a certain multiple, using HPLC to determine the concentration, the results are shown in Table 3.2.P.2.1-1.

The API is weighed appropriately and placed in a brown sample bottle. Different solvents are added according to table 3.2. P.2.1-1 to prepare the corresponding target concentration. The API is evenly dispersed by ultrasound for 20 seconds, then shaken at 200 rpm and 25 ℃ overnight. Then it is taken out and centrifuged at 10000 rpm for 10 times Min, take the supernatant and dilute it with the corresponding solvent in a certain multiple, and then use HPLC to determine the concentration. See table 3.2. P.2.1-1 for the results.<br>