综合运用基于结构的药物设计和经典药物设计策略，设计合成4个系列60-7

Comprehensive use of structure-based drug design and classic drug design strategies, design and synthesize 4 series of 60-70 new derivatives, and perform virtual screening and physical and chemical properties prediction of the designed compounds. Optimize the skeleton of Phenylahistin derivatives, and the area where the molecule occupies less space. 1 Carry out structural optimization and system structure-activity relationship studies to improve drug efficacy and improve physical and chemical properties; use boronic acid groups as triggers to explore to increase selectivity and reduce toxic and side effects .

Using structure-based drug design and classical drug design strategy, the design and synthesis of 4 series of 60-70 new derivatives, and the design of compounds for virtual screening and physical and chemical properties prediction. The skeleton of Phenylahistin derivatives is optimized, and the region where molecules occupy less space1 is studied for structural optimization and system structure relationship to improve the physiotalytic effect and improve the physical and chemical properties;

Four series of 60-70 new derivatives were designed and synthesized by using structure based drug design and classical drug design strategies, and the virtual screening and physicochemical properties prediction of the designed compounds were carried out. In order to improve the pharmacodynamics and physicochemical properties of phenylahistin derivatives, the framework of phenylahistin derivatives was optimized, and the structure of region 1 with less molecular space was optimized and the structure-activity relationship of the system was studied.<br>