Combined with the basis of previous research, we propose that a high-fat diet can play its unique role in inducing high expression of sEH, stimulating the activity of bone-breaking cells, accelerating bone transformation and inflammatory response, and bone angiogenesis can be reduced, bone formation can be inhibited by regulating hiF1 alpha/VEGF signal transduction path.<br><br>Therefore, inhibitory sEH can be used in the treatment of osteoporosis.
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