2019年10月28日10：35，赤霉醇还原岗位9110-R19100

At 10:35 on October 28, 2019, Du Lingjun, a batch of 9110-R191004 batch operators in the gibberellin reduction position, heated the R2003 tank to dissolve the zearalenone and found that the dissolution temperature was 65.4 ℃, which did not meet H3-MPD-10252- 14 The temperature range of 55 ~ 65 ℃ as stipulated in the "Operational Regulations for the Primary Product of Gibberellin (Y69)". <br><br>The deviation occurred because Tang Shoujun, a newly transferred employee in the workshop, did not study the details of the steam heating operation of the reduction position, and did not strictly follow the regulations in H3-MPD-10252-14 "Operation Regulations for Primary Refinery Jobs of Gibberellin (Y69)." During the dissolution of zearalenone, the heating steam pressure was controlled to 0.1Mpa ", and the steam valve was fully opened by mistake, making the heating rate too fast, resulting in the temperature exceeding the range of 55 ~ 65 ℃. <br><br>1. Check the key and important process parameters of gibberellol production in H11-PDR-10002-01R "Gibberellin R & D Report". The temperature of zearalenone dissolution is not considered as an important or key parameter item. Controlling the dissolution temperature of 55-65 ℃ is conducive to the rapid dissolution of zearalenone in isopropanol and the temperature is lower than the reduction reaction temperature of 80-90 ℃, which can avoid affecting the quality of the reduction reaction liquid, so it is considered that the dissolution temperature is 55-65 ℃ It is a non-critical parameter. <br>2. Ask the operators Du Lingjun and Tang Shoujun to know that when the dissolution temperature of zearalenone rises to 65.4 ℃, the dissolution solution has been completely dissolved and the temperature is the highest temperature in the heating process. The time for dissolution and overtemperature lasts about 10 minutes. The temperature of fresh water continued to drop to 43.2 ℃ after cooling down, which was in line with the requirements of 35-45 ℃ for the cooling temperature of aluminum isopropoxide before the feeding of the gibberellin primary refined product post operation rules (Y69). The over-temperature temperature of 65.4 ℃ is still lower than the reduction reaction temperature of 80-90 ℃ and the duration is short, which has almost no effect on the subsequent production and product quality. Summary: In summary, this deviation has no effect on the subsequent production of gibberellol and product quality. <br><br>1. Retrain H3-MPD-10252-14 "Operating Regulations for the Primary Jobs of Gibberellin (Y69)" for all employees of the gibberellol position, emphasizing that the pressure should be strictly controlled in accordance with the SOP requirements when performing the details of heating or cooling operations . And ask whether the employee parameter control is in place.

On October 28, 2019, at 10:35, the operator of the red myenol reduction post 9110-R191004 batch of operator Du Lingjun in the R2003 can for heating dissolved erythromynotone, found that the dissolved temperature is 65.4 degrees C, does not meet the H3-MPD-10252-14 "Chimygal primary product refined operating procedures (Y69C5) temperature range. <br><br>The deviation occurred because the workshop new transfer staff Tang Shoujun to restore the job of steam heating operation details learning is not in place, not strictly in accordance with H3-MPD-10252-14 "Red myosterol once fine products post operating procedures (Y69)" in the process of control heating steam pressure 0.1Mpa", error will be the steam valve completely open, resulting in the heating rate too fast, resulting in temperature of 5 to 5 5 degrees C. <br><br>1. View the key and important process parameters of erythromycin production in H11-PDR-10002-01R The red myosterol research and development report, the melting temperature of erythromycin is not an important or key parameter item. To control the dissolved temperature of 55-65 degrees C is to facilitate the rapid dissolution of erythromycin in isopropyl alcohol and the temperature is lower than the reduced reaction temperature of 80-90 degrees C, thus avoiding the effect of the quality of the reduced reaction fluid, so the dissolution temperature of 55-65 degrees C is considered to be a non-critical parameter.<br>2. Ask operators Du Lingjun and Tang Shoujun learned that the melting temperature of erythromycone has risen to 65.4 degrees C, the dissolved solution has been completely dissolved and the temperature is the highest temperature of the heating process, the dissolving and super-temperature time continued to decline to 43.2 degrees C after the fresh water cooling, in line with the "Redmycin once fine products post operating procedures (Y69)isoalcohol to cool aluminum temperature requirements of 35 degrees C. The super-temperature temperature of 65.4 degrees C is still lower than the reduced reaction temperature of 80-90 degrees C and the duration is short, which has little effect on subsequent production and product quality. Summary: In summary, the deviation has no effect on the subsequent production of erythromycin and product quality.<br><br>1. To all employees of the erythromycin post H3-MPD-10252-14 "Chimytyl once fine products post operating procedures (Y69)" retraining, emphasizing that in the heating or cooling operation details, strictly in accordance with the SOP requirements to control the pressure. And ask the employee if the parameter control is in place.

At 10:35 on October 28, 2019, Du Lingjun, a batch of operators from 9110-r191004 at the gibberellin reduction post, found that the dissolution temperature was 65.4 ℃, which did not meet the temperature range of 55-65 ℃ specified in h3-mpd-10252-14 operating procedures for gibberellin primary refined products post (y69).<br>The reason for this deviation is that Tang Shoujun, a new transferred employee in the workshop, didn't learn the details of steam heating operation in the reduction post in place, and didn't strictly follow the provisions of h3-mpd-10252-14 "operating procedures for primary refined products of gibberellin (y69)" control heating steam pressure 0.1MPa in the process of gibberelline ketone dissolution ", and opened the steam valve completely by mistake, so that the heating rate was too fast, leading to The temperature exceeds 55-65 ℃.<br>1. Check the key and important process parameters of gibberellin production in h11-pdr-10002-01r gibberellin R & D report. Gibberellin ketone dissolution temperature is not an important or key parameter item. Controlling the dissolution temperature of 55-65 ℃ is beneficial to the rapid dissolution of gibberelline in isopropanol and the temperature is lower than the reduction reaction temperature of 80-90 ℃, which can avoid affecting the quality of the reduction reaction solution. Therefore, the dissolution temperature of 55-65 ℃ is considered as a non key parameter.<br>2. Ask the operators Du Lingjun and Tang Shoujun to know that when the dissolution temperature of gibberelline rises to 65.4 ℃, all the solution has been dissolved and the temperature is the highest temperature in the heating process. The time of dissolution and over temperature lasts for about 10 minutes, and the temperature drops to 43.2 ℃ after the fresh water is opened for cooling. It is in accordance with the operating procedures for gibberellin primary refined products (y69) and the temperature before feeding of aluminum isopropanol 3 5 ~ 45 ℃. The overtemperature temperature of 65.4 ℃ is still lower than the reduction reaction temperature of 80-90 ℃ and the duration is short, which has little impact on the follow-up production and product quality. Conclusion: In conclusion, the deviation has no effect on the subsequent production and product quality of gibberellin.<br>1. Retrain h3-mpd-10252-14 "operating procedures for primary refined products of gibberellin (y69)" for all staff of gibberellin post, emphasizing that the pressure shall be strictly controlled in accordance with SOP requirements during the details of temperature rise or temperature drop operation. And ask the staff whether the parameter control is in place.<br>