抗生素是药物史中治疗感染的最重要的药物之一。然而，因为人们广泛地使用抗

Antibiotics are one of the most important drugs for treating infections in the history of drugs. However, because people use antibiotics extensively, drug-resistant bacteria continue to appear in the clinic, and new antibiotics continue to fail. Bacterial drug resistance is a common health concern of all countries in the world, but the development rate of drug-resistant bacteria is far faster than the research speed of antibacterial drugs, so antibacterial drugs with high activity, low toxicity, and no drug resistance have become research antibacterial drugs The top priority. Antimicrobial peptides (AMPs) are naturally present in multicellular organisms. It is used to block microbial infections, so it is called the first level of immune function. It is a peptide substance usually with hydrophilic positive charge and lipophilic side chain. However, antimicrobial peptides have potential shortcomings in vivo toxicity, poor pharmacokinetic properties, etc. These shortcomings restrict the development. The study found that some small-molecule antimicrobial peptide mimics can overcome the shortcomings of antimicrobial peptides while maintaining their own activity, exhibit good antimicrobial activity, low cytotoxicity and low drug resistance, which makes us find a breakthrough point. <br>The antibacterial activity of honokiol is very significant, for example, it has obvious effects on G +, G-, and fungi. It also has anti-tumor effects, anti-aging effects, and cholesterol lowering functions. The study found that Honokiol is a structure with two hydrophobic allyl fatty side chains. They are important groups to exert antibacterial activity. Therefore, based on the molecular structure characteristics of antimicrobial peptides, Honokiol is used as a leader Compounds, the introduction of cationic groups of different lengths such as amino groups on its hydroxyl group, to build the amphiphilic characteristics of the hydrophilic side chain and lipophilic backbone of the compound, to form a spatial structure similar to antibacterial peptides and to study its antibacterial activity. The experimental results show that the designed target compound shows better antibacterial activity than the lead compound.

Antibiotics are one of the most important drugs in the history of medicines to treat infections. However, because of the widespread use of antibiotics, drug-resistant bacteria are constantly emerging in the clinic, and new antibiotics are failing. Bacterial resistance is a common concern of all countries in the world, but the development rate of drug-resistant bacteria far exceeds the research speed of antimicrobial drugs, so the research and development activity is high, low toxicity, non-resistance antimicrobial drugs have become the most important research on antimicrobial drugs. Antimicrobial Peptides (Antimicrobial Peptides, AMPs) are naturally occurring in multicellular organisms. It is used to block microbial infections and is therefore called the first level of immune function. It is a peptide substance that usually has a hydrophilic positive charge and a profattative side chain. However, antimicrobial peptides have potential in vivo toxicity, poor pharmacokinetic properties and other shortcomings, these shortcomings restrict development. The study found that some small molecule antimicrobial peptide simulations can overcome the disadvantages of antimicrobial peptides while maintaining their own activity, showing good antibacterial activity, low cytotoxicity and low resistance, so that we can find a breakthrough point.<br>The antibacterial activity of and thick phenol is very significant, for example, it has obvious effects on G-, G-and fungi. It also has the effect of fighting tumors, the effect of delaying aging, and the function of lowering cholesterol. The study found that and thick purcophenol is a structure with two hydrophobic acrylic side chains, they are an important group of antibacterial activity, therefore, we based on the molecular structure characteristics of antimicrobial peptides, with thick purcophenol as the leading compound, the introduction of different lengths of canonic icing groups such as amino base on the hydroxyl, the construction of compound hydrophilic side chain and lipoid skeleton of the two-parent characteristics, the formation of similar to the antimicrobial peptide spatial structure and antimicrobial activity of the study. The experimental results show that the target compound is designed to show antibacterial activity better than the pilot compound.

Antibiotics are one of the most important drugs in the history of medicine. However, because of the wide use of antibiotics, there are more and more drug-resistant bacteria in clinical practice, and new antibiotics are losing efficacy. Drug resistance of bacteria is a common concern of all countries in the world, but the development speed of drug-resistant bacteria is far faster than the research speed of antibacterial drugs, so the research and development of high activity, low toxicity, non drug resistance of antibacterial drugs has become the top priority. Antimicrobial Peptides (AMPs) are naturally present in multicellular organisms. It is used to block the infection of microorganisms, so it is called the first level of immune function. It is a kind of peptide with hydrophilic positive charge and lipophilic side chain. However, antimicrobial peptides have potential toxicity in vivo and poor pharmacokinetic properties, which restrict their development. It is found that some small molecular antimicrobial peptide analogues can overcome the shortcomings of antimicrobial peptides on the premise of maintaining their own activity, showing good antibacterial activity, low cytotoxicity and low drug resistance, let us find a breakthrough point.<br>For example, it has obvious effect on G +, G -, fungi. At the same time, it has the functions of anti-tumor, anti-aging effect and cholesterol lowering. It is found that honokiol and honokiol are two structures of hydrophobic allylic fatty side chains, and they are important groups to exert antibacterial activity. Therefore, based on the molecular structure characteristics of antibacterial peptides, we take honokiol and honokiol as the lead compounds, introduce cationic groups of different lengths on their hydroxyl groups, such as amino groups, to construct the amphiphilic characteristics of the hydrophilic side chain and lipophilic skeleton of the compounds, The space structure similar to antibacterial peptide was formed and its antibacterial activity was studied. The experimental results show that the designed target compounds show better antibacterial activity than the lead compounds.