Here, we designed chimeric peptides

Here, we designed chimeric peptides to capture exosomes and modify Ti surfaces by connecting CP05 with minTBP-1 directly (P1) or connecting the two through a flexible linker (P2). Ti surfaces modified by the designed chimeric peptides (Ti-P1/P2) were hypothesized to capture more exosomes than immobilized exosomes non-specifically (Ti-EX). The present work demonstrated that chimeric peptides could firmly bind to Ti surfaces, capture exosomes, enhance the loading rate and improve the slow release of exosomes. Furthermore, Ti surface with P2 and exosomes (Ti-P2-EX) promoted the wound healing more efficiently than did Ti surface with P1 and exosomes (Ti-P1-EX) in vivo. This difference is ascribed to the chimeric peptide with linker extending the swing range of CP05 and facilitating the binding between this peptide fragment and exosomes，thus influence cell behavior such as migration and proliferation through a related signaling pathway.

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结果 (英语) 1: [复制]

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Here, we designed chimeric peptides to capture exosomes and modify Ti surfaces by connecting CP05 with minTBP-1 directly (P1) or connecting the two through a flexible linker (P2). Ti surfaces modified by the designed chimeric peptides (Ti-P1/P2 ) were hypothesized to capture more exosomes than immobilized exosomes non-specifically (Ti-EX). The present work demonstrated that chimeric peptides could firmly bind to Ti surfaces, capture exosomes, enhance the loading rate and improve the slow release of exosomes. Furthermore, Ti surface with P2 and exosomes (Ti-P2-EX) promoted the wound healing more efficiently than did Ti surface with P1 and exosomes (Ti-P1-EX) in vivo.This difference is ascribed to the chimeric peptide with linker extending the swing range of CP05 and facilitating the binding between this peptide fragment and exosomes, thus influence cell behavior such as migration and proliferation through a related signaling pathway.

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结果 (英语) 2:[复制]

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结果 (英语) 3:[复制]

复制成功！

在这里，我们设计了嵌合肽，通过直接连接CP05和minTBP-1（P1）或通过柔性连接体（P2）连接二者来捕获外显子和修饰Ti表面。假设由设计的嵌合肽（Ti-P1/P2）修饰的Ti表面比非特异性固定化的外显体（Ti-EX）捕获更多的外显体。本研究表明，嵌合肽能与钛表面牢固结合，捕获外显子，提高外显子的负载率，促进外显子的缓慢释放。此外，含P2和外显子体的Ti表面（Ti-P2-EX）比含P1和外显子体的Ti表面（Ti-P1-EX）在体内更有效地促进伤口愈合。这种差异可归因于嵌合肽与连接子扩展了CP05的摆动范围，促进了肽片段与外显体的结合，从而通过相关的信号通路影响细胞的迁移和增殖等行为。<br>

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