盐酸多柔比星中间体封口、溶解液转移方式的变更：1. 计划在M2309隔

盐酸多柔比星中间体封口、溶解液转移方式的变更：1. 计划在M2309隔离器内新增一个盐酸多柔比星（发酵）专用的投料装置，将R2322密闭移动储罐与该投料装置对接，同时用于盐酸多柔比星一次结晶及二次结晶溶解液转移用。2. 计划将盐酸多柔比星（发酵）产品中间体包装由双层PE袋电热封口变更为双层PE袋扎带封口，取消封口机使用。对M2309隔离器进行改造，增加袋进袋出装置。

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结果 (英语) 1: [复制]

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Changes to the way of sealing and dissolving solution transfer of doxorubicin hydrochloride intermediate: 1. It is planned to add a special dosing device for doxorubicin hydrochloride (fermentation) in the M2309 isolator, and connect the R2322 airtight mobile storage tank with the dosing device For docking, it is also used for the transfer of primary crystallization and secondary crystallization solution of doxorubicin hydrochloride. 2. It is planned to change the packaging of doxorubicin hydrochloride (fermentation) product intermediates from double-layer PE bags with electric heat sealing to double-layer PE bags with strap sealing, and the use of the sealing machine is cancelled. The M2309 isolator was modified and the bag in and bag out device was added.

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结果 (英语) 2:[复制]

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Changes in the mode of sealing and transfer of dissolved fluids in the multi-soft star of hydrochloric acid: 1. It is planned to add a special feeding device for multi-zor ratio star hydrochloride (fermentation) in the M2309 isolator, dock the R2322 closed mobile storage tank with the feeding device, and use it for the transfer of one crystal and two crystal dissolved solutions of the multi-soft star of hydrochloric acid. 2. It is planned to change the intermediate packaging of dorobixing hydrochloric acid (fermentation) products from a double-layer PE bag electric seal to a double-layer PE bag tie seal and cancel the use of the sealing machine. Renovation of the M2309 isolator to increase the bag-in and bag-out device.

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结果 (英语) 3:[复制]

复制成功！

Change of sealing and dissolving solution transfer mode of doxorubicin hydrochloride intermediate: 1. It is planned to add a special feeding device for doxorubicin hydrochloride (fermentation) in m2309 isolator, connect r2322 closed mobile storage tank with the feeding device, and use it for primary crystallization and secondary crystallization solution transfer of doxorubicin hydrochloride. 2. It is planned to change the packaging of intermediate of doxorubicin hydrochloride (fermentation) product from double PE bag electric sealing to double PE bag binding sealing, and cancel the use of sealing machine. The m2309 isolator was modified and the bag inlet and outlet device was added.

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