For example, high methylation of CNR (colorless, non-mature) promoters inhibits the ripening of tomato fruit (Manninget et al., 2006), which is also the origin of the Cnr mutant. In addition, Zhong and his colleagues (Zhong et al., 2013) recently found that global methylation levels gradually declined during the development and maturation of wild-type fruits, but remained high in the fruits of immature Cnr and rin (mature inhibitors) mutants. It is suggested that THE DNA methylation pattern can help regulate the ripening of tomato fruit.
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