When the dosage is too large, the metabolites will damage the liver, cause hemoglobin denaturation and hemolysis, and long-term administration of acetaminophen will also damage the renal function, especially for those with low renal function, taking acetaminophen can cause renal colic or acute renal failure; When the dosage is too large, the metabolites will damage the liver. The dosage threshold of liver necrosis is 250mg / kg. When the dosage is more than 15g at a time, about 80% of them can cause serious liver damage and even death. However, the amount of poisoning is not a fixed value, to a certain extent, it depends on the nutritional status of patients, whether there are complications, combined medication and drinking history.<br>
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