采用DMF（15 mL）把原料和厚朴酚（1.30 g, 5.00 mm

Use DMF (15 mL) to fully dissolve the raw materials and magnolol (1.30 g, 5.00 mmol) to form a solution, then put K2CO3 (2.76 g, 20.00 mmol) and N-Boc-bromoethylamine (6.72 g, 30 mmol) ), increase the temperature to 85 degrees Celsius for the reaction, wait overnight for the raw materials to fully react, pour an appropriate amount of water (100 mL), use a separatory funnel to extract the product multiple times, the solvent used can be ethyl acetate (30 mL ×3). The organic phases obtained from the extraction were mixed together, anhydrous sodium sulfate was used to remove the water, and the solvent was removed with a rotary evaporator to obtain the corresponding crude product. Then, the solid 2 (2.11 g) was obtained by column chromatography, and the color was white. Yield: 76%, mp: 123-125°C.

Dissolve the raw material and thick phenol (1.30 g, 5.00 mmol) fully using DMF (15 mL) to form a solution, followed by K2CO3 (2.76 g, 20.00 mmol) and N-Boc-bromide (6.72 g, 30 mmol), increase the temperature to 85 degrees Celsius to react, wait overnight for the raw material to fully react, pour in the appropriate amount of water (100 mL), using a split funnel to extract the product multiple times, The solvent used can be ethyl acetate (30 mL×3). The extracted organic phase is mixed together, the waterless sodium sulfate is removed, the solvent is removed by rotating evaporator to obtain the corresponding coarse, and the solid 2 (2.11 g) is obtained by column analysis, the color is white. Yield: 76%, mp: 123-125 degrees C.

The raw material and magnolol (1.30 g, 5.00 mmol) were fully dissolved in DMF (15 ml) to form a solution, and then K2CO3 (2.76 g, 20.00 mmol) and n-boc-bromoethylamine (6.72 g, 5.00 mmol) were added into the solution, Increase the temperature to 85 ℃ for reaction, and wait one night for the raw material to fully react. Pour appropriate amount of water (100 ml), and use a separating funnel to extract the product for many times. The solvent used can be ethyl acetate (30 ml × 3). The extracted organic phase was mixed together, and anhydrous sodium sulfate was used to remove the water in it, and the solvent was removed by rotary evaporator to obtain the corresponding crude product. The solid 2 (2.11 g) was obtained by column chromatography, and the color was white. Yield: 76%, MP: 123-125 ℃.<br>