讨论 每年，有超过1900万的人患上败血症，这被定义为继发于感染的威胁

Discussion <br>Every year, more than 19 million people suffer from sepsis, which is defined as a life-threatening acute organ dysfunction secondary to infection, such as infection and heart failure that affect each other and promote its exacerbation [7]. <br><br>Severe sepsis often causes hypofunction of the heart because sepsis affects the calcium ion transport function of myocardial cells, resulting in decreased contractility, enlarged heart, decreased stroke volume, and decreased left ventricular ejection index [8]. This kind of inflammatory factors can cause vasodilatation, increased permeability, hypovolemia and ventricular dysfunction [9]. <br>The incidence of sepsis combined with heart failure is approximately 23.5%. It is an important cause of his death. <br><br>Therefore, timely correction of cardiac function, improvement of microcirculation and rapid reduction of inflammatory mediators in patients are very important for the treatment and prognosis of sepsis. <br><br>Myocardial damage and vascular effects caused by inflammatory factors and sepsis are complicated. Sepsis caused by ureteral stones does not get better after catheterization, and there are still certain risks. <br>Comprehensive medical treatment is often needed until the patient is out of danger. <br><br>Continuous blood purification, as a common treatment method in critical care medicine, is an important means to rescue critically ill patients. <br><br>The filter has in vitro adsorption properties for blood-derived cytokines and other body fluid media of sepsis, which can quickly reduce its accumulation in the body [11]. <br><br>In patients with sepsis who received continuous blood purification, blood levels of inflammatory cytokines including tumor necrosis factor-α, IL-6 and IL-8 and procalcitonin were found to be significantly lower than those in the conventional treatment group 【12】. <br><br>Other studies have confirmed that continuous blood purification has significant changes in the levels of calcitonin (PCT) and other inflammatory markers before and after treatment in patients with septic shock [13]. <br><br>This study confirmed that before treatment, the levels of TNF-a, CRP, and PCT in the experimental group and the control group were significantly higher than normal, and there was no significant difference between the two groups (p>0.05). After treatment, all groups were significantly lower than before treatment. The experimental group improved more significantly (p

Discuss.<br> Every year, more than 19 million people develop sepsis, defined as a secondary infection of life-threatening acute organ dysfunction, such as infection and heart failure, which affects and exacerbates it.<br><br>Severe sepsis often causes cardiac dysfunction because sepsis affects the transport of calcium ions in myocardial cells, resulting in reduced contraction, enlargement of the heart, output per beat, lower left-room blood index, while various inflammatory factors can lead to blood vessel dilation, increased permeability, insufficient blood volume and dysfunction of the heart.<br>The combined heart failure rate of sepsis is about 23.5%. is an important cause of death.<br><br>Therefore, timely correction of heart function to improve microcirculation and rapidly reduce inflammatory media in patients is very important for the treatment and prognosis of sepsis.<br><br>Due to inflammatory factors and sepsis caused by heart muscle damage and complex vascular influence mechanism, sepsis caused by ureter stones in some patients can not quickly improve after the tube, there is still a certain risk.<br>Comprehensive medical treatment is often required until the patient is out of danger.<br><br>Continuous blood purification, as a commonly used treatment method in critical medicine, is an important means to rescue critically ill patients.<br><br>The filter has in vitro adsorption properties on blood-sourced cytokines and other body fluid media of sepsis, which can quickly reduce its accumulation in the body.<br><br>In patients receiving continuous blood purification of sepsis, inflammatory cytokines, including tumor necrosis factors -α, IL-6 and IL-8, were found to have significantly lower blood levels than in conventional treatment groups.<br><br>Other studies have confirmed that continuous blood purification of calcitonin (PCT) and other inflammatory markers changed significantly before and after treatment in patients with sepsis shock.<br><br>The study confirmed that the water level of TNF-a, CRP and PCT in the experimental and control groups was significantly higher than normal before treatment, and that there was no significant difference between the two groups (p>0.05). After treatment, each group was significantly lower than before treatment. The improvement in the experimental group was more pronounced (p.

discuss<br>Each year, more than 19 million people suffer from sepsis, which is defined as life-threatening acute organ dysfunction secondary to infection, such as infection and heart failure, which interact and promote their exacerbation [7].<br>The reason why severe sepsis often causes cardiac dysfunction is that sepsis affects the calcium ion transport function of myocardial cells, resulting in decreased contractility, cardiac enlargement, stroke volume and left ventricular ejection index [8]. At the same time, various inflammatory factors can lead to vasodilation, increased permeability, insufficient blood volume and ventricular dysfunction [9].<br>The incidence of sepsis complicated with heart failure was about 23.5%. It is an important cause of death.<br>Therefore, timely correction of cardiac function, improvement of microcirculation and rapid reduction of inflammatory mediators in patients with sepsis are very important for the treatment and prognosis of sepsis.<br>Because of the complex mechanism of myocardial injury and vascular impact caused by inflammatory factors and sepsis, some patients with ureteral stone sepsis can not improve quickly after catheterization, and there are still some risks.<br>Comprehensive medical treatment is often needed until the patient is out of danger.<br>Continuous blood purification, as a common treatment method in the Department of critical medicine, is an important means to rescue critical patients.<br>The filter has in vitro adsorption characteristics on blood-derived cytokines and other humoral media of sepsis, and can quickly reduce its accumulation in vivo [11].<br>In sepsis patients receiving continuous blood purification, the blood levels of inflammatory cytokines including tumor necrosis factor - α, IL-6 and IL-8, and procalcitonin were significantly lower than those in the conventional treatment group [12].<br>Other studies have confirmed that continuous blood purification can significantly change the levels of calcitonin (PCT) and other inflammatory markers in patients with septic shock before and after treatment [13].<br>This study confirmed that before treatment, the levels of TNF-a, CRP and PCT in the experimental group and the control group were significantly higher than the normal value, and there was no significant difference between the two groups (P > 0.05). After treatment, all groups were significantly lower than before treatment. The improvement was more obvious in the experimental group (P<br>