免疫抑制剂现在最主要的问题，激素是长期应用大剂量所带来的问题，短时间应

The main problem of immunosuppressants now is that hormones are caused by long-term use of large doses. Short-term use generally has relatively small side effects, but the treatment of hormones is relatively long and the dose is relatively large, so there are other infections caused The probability of hormone-related complications is very high. Nowadays, biologically targeted drugs are mainly allergic to biological agents, and the allergic reaction to biological agents is quite prominent when the drug is used. The second is that long-term accumulation of targeted drugs can also control the patient's cellular immunity to a lower level, and it can also cause opportunistic infections. So in this point, I think it is basically no different from other immunosuppressive agents, but there is no difference in prone to opportunistic infections.

免疫抑制剂现在最主要的问题，激素是长期应用大剂量所带来的问题，短时间应用一般副作用还是比较小的，但是激素的疗程比较长，剂量比较大，所以带来的感染还有其他跟激素相关的并发症概率是非常高的，现在生物靶向药物主要是生物制剂的过敏，在当次用药时生物制剂过敏反应还是比较突出的。第二个是长期累计靶向药物也一样能把病人的细胞免疫控制的比较低，一样可以有机会性感染的发生。所以这点来说我想跟其他免疫抑制剂在根本上没有区别，只是在容易发生机会性感染上没有区别。

The main problem of immunosuppressants is that hormone is caused by long-term use of high-dose, and the side effects of short-term application are relatively small. However, the course of treatment of hormone is relatively long and the dose is relatively large. Therefore, the probability of infection and other hormone related complications is very high. Now the biological targeted drugs are mainly allergic to biological agents, which are used at the current time The allergic reaction of biological agents is more prominent. The second is that the long-term accumulation of targeted drugs can also lower the cellular immune control of patients, as well as the occurrence of opportunistic infections. So in this point, I think there is no difference with other immunosuppressants, but there is no difference in the susceptibility to opportunistic infections.