氮硫（硒）杂环化合物在化学、药学、生物学和材料科学等领域具有广阔的应用

Nitrogen-sulfur (selenium) heterocyclic compounds have broad application prospects in the fields of chemistry, pharmacy, biology, and materials science. Chemists have developed various methods to construct nitrogen-sulfur (selenium) heterocyclic compound skeletons, among which transition metals are used Catalytic CH functionalization/cyclization reaction to construct nitrogen-sulfur heterocyclic compounds is a very effective method. Currently, chemists have developed a variety of effective methods to construct common five-membered nitrogen-sulfur (selenium) heterocyclic compounds such as benzothiazole, but for six-membered nitrogen-sulfur (selenium) heterocyclic compounds and five-membered heterocyclic benzisothiophene ( Selenium)azoles, especially benzo[c]isothi (selenium)azoles, still lack effective synthesis methods. This project intends to use the easily available and stable N-(1-phenylethyl)aniline compounds and o-alkynyl arylamines as substrates to undergo a series cyclization reaction with an inorganic sulfur (selenium) source to construct thi(selenium)azine compounds and benzo[c]isothi (selenium) azoles. Through substrate design and condition optimization, develop an efficient, highly selective, and mild-condition transition metal-catalyzed tandem cyclization method to synthesize nitrogen, sulfur (selenium) cyclic compounds; at the same time, explore the reaction mechanism through modern analysis and testing methods; and This method and technology are applied to the synthesis of some natural products and drug molecules and frameworks. Provide theoretical and experimental basis for the synthesis and application research of nitrogen, sulfur (selenium) heterocyclic compounds.

Nitrogen sulfur (selenium) heterocyclic compounds have broad application prospects in fields such as chemistry, pharmacy, biology, and materials science. Chemists have developed various methods to construct the skeleton of nitrogen sulfur (selenium) heterocyclic compounds, among which the use of transition metal catalyzed C-H functionalization/cyclization reaction to construct nitrogen sulfur heterocyclic compounds is a very effective method. At present, chemists have developed various effective methods to construct common five membered nitrogen sulfur (selenium) heterocyclic compounds such as benzothiazole, but there is still a lack of effective synthesis methods for six membered nitrogen sulfur (selenium) heterocyclic and five membered heterocyclic benzoisothiazole, especially benzo [c] isothiazole. This project aims to use simple and stable N - (1-phenylethyl) aniline compounds and o-alkynylarylamines as substrates to undergo a series cyclization reaction with inorganic sulfur (selenium) sources to construct thiazine compounds and benzo [c] isothiazole compounds. Develop efficient, highly selective, and mild transition metal catalyzed series cyclization reactions to synthesize nitrogen sulfur (selenium) cyclic compounds through substrate design and condition optimization; Simultaneously, explore the reaction mechanism through modern analysis and testing methods; And apply this method and technology to the synthesis of some natural products and drug molecules and frameworks. Provide theoretical and experimental basis for the synthesis and application research of nitrogen sulfur (selenium) heterocyclic compounds.

I see,<br> Simply speaking, investing is just a matter of habit. If you learn enough knowledge and experience and are familiar with the rules of the stock market, you can achieve your ideal wealth goal. Nitrogen-sulfur (selenium) heterocyclic compounds have broad application prospects in the fields of chemistry, pharmacy, biology and material science. Chemists have developed various methods to construct the skeleton of nitrogen-sulfur (selenium) heterocyclic compounds, among which the C-H functionalization/cyclization reaction catalyzed by transition metals is a very effective method to construct nitrogen-sulfur heterocyclic compounds. At present, chemists have developed many effective methods to construct common five-membered nitrogen-sulfur (selenium) heterocyclic compounds such as benzothiazole, but there is still a lack of effective synthesis methods for six-membered nitrogen-sulfur (selenium) heterocyclic compounds and five-membered heterocyclic benzisothiazoles, especially benzo [c] isothiazoles. In this project, simple, easily available and stable N-(1- phenylethyl) aniline compounds and o-alkynyl arylamine are used as substrates to undergo a series cyclization reaction with inorganic sulfur (selenium) sources to construct thiazines and benzo [c] isothiazoles. Through substrate design and condition optimization, a method of synthesizing nitrogen-sulfur (selenium) cyclic compounds by series cyclization catalyzed by transition metals with high efficiency, high selectivity and mild conditions was developed. At the same time, the reaction mechanism was explored by modern analysis and testing methods. The method and technology are applied to the synthesis of some natural products and drug molecules and skeletons. It provides theoretical and experimental basis for the synthesis and application of nitrogen-sulfur (selenium) heterocyclic compounds.