This deviation is due to personnel's inadequate implementation of SOP and equipment reasons. The quaternary proportional valve of this instrument needs to be cleaned with isopropanol and re-calibrated. And check all the HPLC cleaning conditions of the analytical technology department. If it is not cleaned with isopropanol, it needs to be cleaned with isopropanol. Check that the gradient ratio deviation of this calibration is not very large, the maximum is -6.64%, indicating that the internal leakage of the A pump is not very serious. The internal leakage of the pump A has no effect on the isocratic experiment, and does not have a great influence on the gradient experiment results. Through the investigation of the latest 3 gradient experiments, the system adaptability meets the requirements, the retention time is stable, and it is compared with the history of other instruments. In comparison, they are basically the same. Therefore, the comprehensive evaluation has no effect on the results of the products tested by this instrument. . <br>For further details, please refer to: D-TZ-API-EG-21001-R.
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