At 11:04 on June 6, 2019, when Sun Wenjie, a technician, printed the sterilization and culture history curve of 5001-a190513 batches in the fermentation batch record of acarbose that had been put into the tank on that day, he found that the culture cycle of 106 tanks in the primary seed tank was zero between 17:30 and 18:03 on May 31, 2019.<br>The root cause of this deviation is that the 106 tank cycle calculation block in the CPU block of the hardware Honeywell DCS system is jammed or abnormal, which causes the 106 tank culture cycle to zero in a short time.<br>The primary seed tank 106 corresponding to the batch 5001-a190513 history curve in the acarbose fermentation batch record showed zero culture cycle between 17:30 and 18:03 on May 31, 2019. The period indicates the length of fermentation culture time, which will not affect other fermentation parameters; when the deviation occurs, the computer display is normal, and the post operators operate according to SOP during the shift, and no abnormality is found; from the historical curve, other fermentation parameter curves of tank 106 are normal, so it is considered that this deviation has no impact on the fermentation culture of tank 106.<br>1. follow up the operation of the computer control system of the fermentation post for 6 months, and confirm whether the abnormal operation of the fermentation tank cycle occurs again due to the clamping or abnormal phenomenon of the program block in the CPU program block of the hardware Honeywell DCS system that specially calculates the operation of the fermentation cycle
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