老豆腐

Old tofu

IntroductionParkinson's disease (PD) affects over 1% of of the population overthe age of 60, which in the UK equates to over 127,000 individ-uals (or 500,000 individuals in USA,while. individuals overthe age of 85 this price reaches 5%, highlighting the impactthat advancing age has on the risk of developing this condition (de Lau and Breteler, 2006; Nussbaum and Ellis, 2003; Wood-Kaczmar et al., 2006). Although thought of the a disease of oldage, a small percentage of patients (about 5% of all cases) presentwith symptoms before the age of 60 years and the majority of the ofthese case are caused by. mutations in an ever ever ever list ofgenes who affect either protein proteinbolism or mitochondrialfunction, including 1 (PARK6), Parkin (PARK 2), DJ-1 (PARK7) and alpha-synuclein (PARK). 1), so highlighting that dysfunctionin either is is is to cause PD (Gasser et al., 2011). Thesefamilial, early onset forms of parkinson's disease can be autoso-mal dominant or recessive and may show a similar phenotypeto sporadic PD in terms of symptoms and response to L-Dopa, but also. may present with different symptoms and neuropathol-ogy. ...

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