2019年12月14日04时28分，109车间Y10幢北发酵2#自控电

At 04:28 on December 14, 2019, the Y10 building North Fermentation 2 # automatic control computer in Workshop 109 issued a second-level alarm. After inspection by Xu Xiuzhi, it was found that it was 205 seeds of adenosylmethionine 1,4-butanedisulfonate 9001-191203 The pH high limit alarm of the tank (at this time, the pH high limit alarm parameter is set to 5.50, the pH high high limit alarm parameter is set to 7.00, the pH of the 205 seed tank is displayed as 7.21), and the fermentation cycle is 7h (8 ~ 17h). After viewing the historical curve, it was found that the pH of the 205 fermentor suddenly increased from 4.52 to 7.21 at 04:27, directly exceeding the process range (4.00 ~ 7.00). There is not enough time to adjust it when a primary alarm occurs. The pH of the 205 seed tank reached the highest point of 9.64 at 05:58, and the pH was 9.21 at 09:50, which has not recovered to the process range (the fermentation cycle is 13h at this time).

On December 14, 2019, at 04:28, 109 workshop Y10 North Fermentation 2 self-control computer issued a secondary alarm, after Xu Xiuzhi looked at the results found to be 1,4-butyl sulfonate aseptic methionine 9001-191203 Batch 205 seed tank pH high limit alarm (at this time pH high limit alarm parameters set to 5.50, pH high limit alarm parameters set to 7.00, 205 seed tank pH display edg 7.21), at this time fermentation cycle is 7h (8 to 17h). A review of the historical curve showed that the pH of the 205 fermentation tank suddenly rose rapidly from 4.52 to 7.21 at 04:27, directly beyond the process range (4.00 to 7.00). There is not enough time to adjust the level 1 alarm. The 205 seed tank pH reached a peak of 9.64 at 05:58 and at 9.21 pH at 0950 pH, which is still not restored to the process range (at this time the fermentation cycle is 13h).

At 04:28 on December 14, 2019, the automatic control computer in building Y10 of workshop 109 sent out a secondary alarm, which was found by Xu Xiuzhi to be 1, The alarm for high pH limit of 205 seed tank in batch 4-ademetionine-succinate 9001-191203 (at this time, the alarm parameter of high pH limit is set to 5.50, and the alarm parameter of high pH limit is set to 7.00205, and the pH value of seed tank is set to 7.21), and the fermentation cycle is 7h (8-17h). Looking at the historical curve, it was found that the pH of 205 fermentation tank suddenly increased from 4.52 to 7.21 at 04:27, which directly exceeded the process range (4.00 ~ 7.00). There is not enough time to adjust the primary alarm when it occurs. At 05:58, the pH of 205 seed tank reached the highest point of 9.64, and at 09:50, the pH was 9.21, which was still not restored to the process range (at this time, the fermentation cycle was 13h).<br>