发明名称一种新颖的6-氨基-1H-吡唑并[3,4-d]嘧啶类JAK激酶

发明名称一种新颖的6-氨基-1H-吡唑并[3,4-d]嘧啶类JAK激酶抑制剂的制备与应用摘要本发明提供了可用于预防、治疗和/或改善自身免疫疾病（例如，牛皮癣、类风湿性关节炎、炎性肠炎疾病、斯耶格伦氏综合征、白塞氏病、多发性硬化、系统性红斑狼疮等）的药物，其具有优良的JAK激酶（Janus Kinase）抑制活性。本发明还提供包含所述化合物的药学上可接受的组合物和用于制备这些化合物的方法。

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结果 (英语) 1: [复制]

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Name of the invention : Preparation and application of a novel 6-amino-1H-pyrazolo[3,4-d]pyrimidine JAK kinase inhibitor. Abstract The present invention provides a method for preventing, treating and/or improving autoimmune diseases ( For example, drugs for psoriasis, rheumatoid arthritis, inflammatory bowel disease, Sjogren’s syndrome, Behçet’s disease, multiple sclerosis, systemic lupus erythematosus, etc.) have excellent JAK kinase (Janus Kinase ) Inhibition of activity. The present invention also provides pharmaceutically acceptable compositions containing the compounds and methods for preparing these compounds.

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结果 (英语) 2:[复制]

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The name of the invention Preparation and application of a novel 6-amino-1H-pyridine and JAK kinase inhibitors Summary The invention provides a drug that can be used to prevent, treat and/or improve autoimmune diseases (e.g., psoriasis, rheumatoid arthritis, inflammatory enteritis disease, Sjegren's syndrome, beetle's disease, multiple sclerosis, systemic lupus erythematosus, etc.), which has excellent JAK kinase (Janus Kinase) inhibition activity. The invention also provides a pharmaceutically acceptable composition containing the compound and a method for the preparation of these compounds.

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结果 (英语) 3:[复制]

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Name of invention Preparation and application of a novel 6-amino-1h-pyrazolo [3,4-d] pyrimidine JAK kinase inhibitor abstract The invention provides drugs that can be used to prevent, treat and / or improve autoimmune diseases (e.g., psoriasis, rheumatoid arthritis, inflammatory enteritis, Sjogren's syndrome, Behcet's disease, multiple sclerosis, systemic lupus erythematosus, etc.), which have excellent JAK kinase inhibitory activity. The invention also provides pharmaceutically acceptable compositions comprising the compounds and methods for preparing the compounds.

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