In this project, we conducted in-depth study on the mechanism of action of natural copper and saponin Ⅵ of Dipsacus aspectus, and verified that they jointly regulate ATF4, an important transcription factor of osteogenic differentiation, through synergistic action, so as to improve the efficiency of fracture healing. It provides a new clue for optimizing drug compatibility, improving drug efficacy and developing new drugs.<br>
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