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Many drugs are derived from natural products. But before natural products can be exploited, chemists must first determine their structure and stereochemistry. This can be a major challenge, particularly when the molecules cannot be crystallized and contain only few hydrogen atoms. A new NMR-based method, developed at the Leibniz-Forschungsst fér Molekulare Pharmakologie (FMP), now simplifies th e analysis and produces more accurate results. The work has been published in the Journal of the American Chemical Society.<br><br>Natural products are present in antibiotics, painkillers and cancer drugs, playing a key role in around 60 percent of all FDA approved drugs. Plants、 fungi and sessile marine organisms are particularly promising sources、 because many of them poss chemical defen セズ・トゥ・デ・ター・プラデア However, identification of potential drug candidates is a challenge. First は、 "sers must accurately determine the structure and stereochemistry (the spatial arrangement of atoms) of the m オレキュール Without this information, chemists will be unable to synthesize the molecules and develop them into drugs. Moreover, the structure is needed to establish whether the molecule has previously been discovered.<br><br>Besides the X-ray diffraction method, which can only be applied to the crystallizable molecules, chemists usually use nucl ear magnetic resonance (NMR) spectroscopy for structure determination. Most recently, the NMR-based parameter __ residual chemical shift anisotropy" has taken on particular importance in this c ontext. Studies from the past two to three years have shown that this parameter facilitates the very accurate determination of the the the ストークチュアとstereochemistry of organic molecules. However, this requires the use of special instruments that are not available in all laboratories. and then there is the matter of time-consuming methods of analysis involved in data analysis.

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